Aristides Eliopoulos, PhD
Department of Basic Sciences –
University of Crete Medical School
Affiliated member: Institute of Molecular Biology and Biotechnology - FORTH
Lab web page: http://mcb.med.uoc.gr
Cancer is a complex disease which is often characterized by deregulated intracellular signal transduction. Our current research explores:
Epidemiological, clinical and experimental data suggest that a number of human malignancies can be attributed to toxic agents and irritants or to persistent infections of viral or bacterial etiology which cause chronic inflammatory imbalance in the affected tissue. We utilize chemical-induced carcinogenesis protocols in animal models to dissect the role of the various cell types present in the tumor and analyze the signals exchanged between these cells with emphasis on the TPL2 kinase. The practical benefits of this research will assist in the improved design of novel anti-cancer therapeutics and diagnostic tools to address prevention, early detection and improved management of human cancer.