Karagogeos

Domna Karagogeos, PhD

Member

 

Professor of Molecular Biology-Developmental Neurobiology

Department of Basic Sciences –

University of Crete Medical School

Affiliated member: Institute of Molecular Biology and Biotechnology - FORTH

Email address: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone

+30-2810-394542

Fax

+30-2810-394530

Lab web page

http://www.imbb.forth.gr/karagogeos

 

Research

Neuronal development

We focus in the field of axon guidance and neuronal migration during development. It is well established that both of these events are crucial to the patterning of specific neural connections that are set-up during development. In particular we are working with signals that are mediating contact-dependent guidance and migration. Ongoing research projects includes:

  1. - The cellular and molecular mechanisms involved in tangential migrations in the hindbrain and in the cortex.
  2. - The role of small GTPases in cortical interneuron development.
  3. - The role of adhesion molecule TAG-1 in corticofugal axon guidance.
  4. - The role of TAG-1 in olfactory system organization
  5. - The alterations of myelinated fiber domains in demyelination mouse models and in multiple sclerosis
  6. - The role of TAG-1 in demyelination/remyelination
  7. - The identification of new interactors or downstream effectors of glial TAG-1

Myelination

We are interested in the molecular organization and functional architecture of myelinated fibers. Myelinated fibers are organized into distinct functional domains. The proper organization of myelinated fibers is crucial for the rapid propagation of action potentials along the axon. In pathological conditions such as multiple sclerosis or a number of neuropathies, the architecture of myelinated fibers is disrupted. Ongoing projects include analysis of:

 

  1. The alterations of myelinated fiber domains in demyelination mouse models and in multiple sclerosis
  2. The role of TAG-1 in demyelination/remyelination
  3. The identification of new interactors or downstream effectors of glial TAG-1