George Goulielmos, PhD
Professor of Human Molecular Genetics
Section of Molecular Pathology and Human Genetics
Department of Internal Medicine
University of Crete Medical School
Tel: 2810-394626, 2810-394673
The bidirectional interaction between basic and clinical sciences in Medicine has provided the impetus to the rapid development of Molecular Medicine. Most of the genes involved in the major monogenic disorders have now been isolated and characterized Complex diseases represent the most common and the least understood human diseases. Identification of genetic factors predisposing individuals to diseases is a powerful tool since offers the opportunity for prevention or treatment of several diseases.
The focus of our research is on the investigation of key pathogenetic events in a variety of metabolic, infectious and inflammatory diseases. The main emphasis is on investigating the naturally selected critical pathways in acute and chronic inflammations of infectious or auto-inflammatory nature. More specifically, we are interested in:
a) Understanding the pathogenic mechanisms leading to the development of Familial Mediterranean Fever (FMF), the prototype of the autoinflammatory (recurrent fever) syndromes.
b) Searching for new genes and microRNAs involved in the development of FMF.
c) Understanding the genetics of endometriosis as well as various autoimmune diseases, resulting from the deregulation of the immune system, such as Systemic lupus erythematosus (SLE), Rheumatoid arthritis (RA), Juvenile idiopathic arthritis (JIA), Type 1 Diabetes (T1D), Multiple Sclerosis (MS), Ankylosing Spondylitis (AS), Psoriasis (PS) and Psoriatic arthritis (PsA).
d) Exploring the structural/functional significance of various gene polymorphisms and gaining insight into new molecular pathways leading to the development of various autoimmune diseases as well as endometriosis, by using functional genetics and approaches of structural biology (3D modeling, homology modeling etc).
f) Identifying genetic risk factors for complex diseases, i.e. Type 2 diabetes (T2D), Osteoarthritis, Primary open-angle glaucoma (POAG), Acute lymphoblastic leukemia (ALL) and Chronic Idiopathic Neutropenia (CIN).
g) Developing gene panels for patients’ targeted genotyping for various genes involved in the development of autoinflammatory and complex diseases.
Our research has been funded by the FP5, FP6 (Autocure), HEALTH (“ALCOVE - Joint Action Alzheimer”), FP7 (BTCure) EU programs and the Ministries of Education and Development of Greece (“Thalis”, “Aristeia”, “Irakleitos”, “Synergasia”, “Archimedes” and ESPA 2014-2020 calls).