Giorgos Sourvinos

 

George Sourvinos, PhD

Member

Department of Laboratory Medicine –

Medical School, University of Crete

 

email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Tel: 2810-394835

 

Lab web page: http://www.med.uoc.gr/arxeia/cv/cv-sourvinos-george_gr.pdf

Research

 

The main interest of our group concerns the control of both HSV-1 and HCMV gene expression during lytic and quiescent infection and the analysis of the virus-host interactions at early stages of the infection. The above questions are approached in a multidisciplinary way, using a variety of techniques of Cell Biology and most important of them, monitoring of live infected cells. Genetically engineered viruses are constructed, expressing autofluorescent proteins (e.g. EGFP) fused to viral proteins, enabling the visualisation of their dynamics. Furthermore, the experimental approaches utilise a variety of molecular genetic techniques such as gene cloning and expression, transient transfection assays and biochemical assays of enzyme activity.

Specific aims:

- Regulation of Herpes Simplex Virus type-1 (HSV-1) and Human Cytomegalovirus (HCMV) gene expression during lytic infection and latency.

- The role of Rho GTPases during HCMV infection.

- Signaling pathways activated during HSV-1 lytic infection, latency and reactivation.

- Epigenetic regulation of HCMV infection by the Polycomb Repressive Complexes.

- Activation of inflammatory and epigenetic pathways during HCMV productive infection

via miRNAs of the host.

 

Our research is funded by the EU FP7 program, the Ministry of Education, Research & Religious Affairs of Hellas and the Special Account for Research of the University of Crete.