katerina Vaporidi2 

 

Katerina Vaporidi, MD, PhD

Member

Head of the Experimental Intensive Care Medicine Laboratory

Department of Intensive Care Medicine –

University of Crete Medical School

email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Tel: 2810-394729

Lab web page: http://icu.med.uoc.gr/english/lab-experimental-icm.html

 

Research

Research at the laboratory of Intensive Care Medicine focuses on mechanisms of common pathologic conditions encountered in Intensive Care that have significant effects on patient outcome, specifically sepsis, acute lung injury (ALI - ARDS) and ventilator-induced lung injury (VILI). Sepsis is major health-care problem worldwide, and among the most common reasons for ICU admission, still associated with mortality of 40%. Acute lung injury or ARDS is the most common pulmonary complication of sepsis, but also of trauma, pneumonia, burn injury and other common conditions resulting in respiratory failure and need for ICU and mechanical ventilation. ARDS mortality is also about 40%, and can be  worsen by mechanical ventilation, a condition termed ventilator-induced lung injury. We use mouse models to study:

a) mechanisms that contribute to ventilator lung injury

b) mechanisms of sepsis-induced lung injury

c) Characterizing the immune system dysfunctions occurring at the late stages of sepsis